Anti-Human CD276 Recombinant Antibody (TAB-117CL)
CAT#: TAB-117CL
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human CD276. This antibody is a first-in-class, humanized IgG1κ monoclonal antibody that recognizes human B7-H3, a novel member of the B7 family of immune regulators. This antibody has been Fc-engineered to further augment its tumor killing activity.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 CD276 Recombinant Antibody (TAB-117CL) in SDS-PAGE
SDS-PAGE analysis of TAB-117CL in non-reduced (Lane 1) and β-mercaptoethanol-reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 CD276 Recombinant Antibody (TAB-117CL) in HPLC
The purity of TAB-117CL was greater than 95% as determined by SEC-HPLC.
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Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17139/if_selected.jpg
Normal Tissue
Figure 2 Placenta.
High expression in placenta
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17826/40943_A_1_7_val_selected.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_5_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9285/25731_A_7_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, U-2197)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000103855-CD276
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Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- ADCC, FuncS
- Related Disease
- Solid Tumors
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- This antibody has been tested for use in Antibody-dependent Cellular Cytotoxicity Assay and Functional Assay.
Target
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(Creative Biolabs Cat# TAB-117CL, RRID: AB_3111822)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1603MZ | Mouse Anti-CD276 Recombinant Antibody (clone NJI53) | FC | Mouse IgG1 |
| HPAB-0241-CN | Human Anti-CD276 Recombinant Antibody (HPAB-0241-CN) | ELISA, FC, IP | Chimeric (mouse/human) IgG1, κ |
| HPAB-M0422-YC | Mouse Anti-CD276 Recombinant Antibody (HPAB-M0422-YC) | Cyt, FuncS | Mouse IgG |
| HPAB-M0423-YC | Mouse Anti-CD276 Recombinant Antibody (HPAB-M0423-YC) | Cyt, FuncS | Mouse IgG |
| HPAB-M0424-YC | Human Anti-CD276 Recombinant Antibody (HPAB-M0424-YC) | Cyt, FuncS, IHC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-333CQ | Rat Anti-CD276 Recombinant Antibody (clone MJ18) | Block, FC | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0549 | Hi-Affi™ Rabbit Anti-CD276 Recombinant Antibody (clone DS549AB) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-424CQ | Anti-Human CD276 Recombinant Antibody (TAB-424CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0234-CN-S(P) | Human Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-0234-CN-S(P)) | ELISA, FC, IF | Human scFv |
| HPAB-0236-CN-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-0236-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0237-CN-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-0237-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0238-CN-S(P) | Mouse Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-0238-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
| HPAB-0239-CN-S(P) | Human Anti-CD276 Recombinant Antibody; scFv Fragment (HPAB-0239-CN-S(P)) | ELISA, FC, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0048LY-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0048LY-F(E)) | FuncS, ELISA, FC, IHC | Mouse Fab |
| HPAB-0049LY-F(E) | Human Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-0049LY-F(E)) | FuncS, ELISA, FC, IHC | Humanized Fab |
| HPAB-M0422-YC-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-M0422-YC-F(E)) | Cyt, FuncS | Mouse Fab |
| HPAB-M0423-YC-F(E) | Mouse Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-M0423-YC-F(E)) | Cyt, FuncS | Mouse Fab |
| HPAB-M0424-YC-F(E) | Human Anti-CD276 Recombinant Antibody; Fab Fragment (HPAB-M0424-YC-F(E)) | Cyt, FuncS, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-424CQ | Afuco™ Anti-CD276 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-424CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1279 | AbPlus™ Anti-Cd276 Magnetic Beads (VS-0724-YC1279) | IP, Protein Purification | |
| VS-0724-YC1280 | AbPlus™ Anti-Cd276 Magnetic Beads (VS-0724-YC1280) | IP, Protein Purification | |
| VS-0724-YC1366 | AbPlus™ Anti-CD276 Magnetic Beads (VS-0724-YC1366) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY67 | Human Anti-CD276 (clone MGA271) scFv-Fc Chimera | ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC156 | Recombinant Anti-CD276 Vesicular Antibody, EV Displayed (VS-0425-YC156) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1155 | Anti-CD276 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1156 | Anti-Mouse CD276 Immunohistochemistry Kit | IHC |
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